Model-based investigation of intracellular processes determining antibody Fc-glycosylation under mild hypothermia
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چکیده
منابع مشابه
Model‐based investigation of intracellular processes determining antibody Fc‐glycosylation under mild hypothermia
Despite the positive effects of mild hypothermic conditions on monoclonal antibody (mAb) productivity (qmAb ) during mammalian cell culture, the impact of reduced culture temperature on mAb Fc-glycosylation and the mechanism behind changes in the glycan composition are not fully established. The lack of knowledge about the regulation of dynamic intracellular processes under mild hypothermia res...
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Immunoglobulins and Fc receptors are critical glycoprotein components of the immune system. Fc receptors bind the Fc (effector) region of antibody molecules and communicate information within the innate and adaptive immune systems. Glycosylation of antibodies, particularly in the Fc region of IgG, has been extensively studied in health and disease. The N-glycans in the identical heavy chains ha...
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ژورنال
عنوان ژورنال: Biotechnology and Bioengineering
سال: 2017
ISSN: 0006-3592
DOI: 10.1002/bit.26225